PDE2A (human, recombinant; aa 215-900) - 深圳欣博盛生物科技有限公司

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PDE2A (human, recombinant; aa 215-900)

品牌： Cayman

产品货号： 32037

规格： 50 µg

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数量： - +

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产品名称:

PDE2A (human, recombinant; aa 215-900)
别名:

CGMP-Dependent 3',5'-Cyclic Phosphodiesterase|CGS-PDE|Cyclic GMP-Stimulated Phosphodiesterase|Phosphodiesterase 2A, CGMP-Stimulated
产品描述:

Phosphodiesterase 2A (PDE2A) is a cGMP-stimulated cyclic nucleotide phosphodiesterase that hydrolyzes cGMP and cAMP.{46998} It is a 941-amino acid protein comprised of an N-terminal domain (1-214), GAF-A domain (215-372), GAF-B domain (393-541), and a catalytic domain (579-941) and functions as a homodimer.{46999} PDE2A is expressed in the brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney, spleen, and pituitary.{57000} Upon cGMP binding to the GAF-B domain, PDE2A is activated and hydrolyzes cAMP and cGMP to regulate cell signaling.{46998} PDE2A mRNA levels are reduced in postmortem amygdala from patients with schizophrenia, bipolar disorder, and major depressive disorder compared with healthy controls.{57001} PDE2A brain activity is increased in the Fmr1-/- mouse model of fragile X syndrome and administration of the selective PDE2A inhibitor BAY 60-7550 (Item No. 10011135) restores axonal length and spine maturation and attenuates social discriminatory and vocalization deficits in Fmr1-/- young mice.{57002} Adenovirus shRNA knockdown of Pde2a attenuates bronchoalveolar lavage fluid (BALF) neutrophilia, reduces lung levels of inducible nitric oxide synthase (iNOS), and increases lung cAMP levels in a mouse model of acute lung injury.{57003} Cayman’s PDE2A (human, recombinant; aa 215-900) protein consists of 706 amino acids and has a calculated molecular weight of 80 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 66 kDa.
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-80
运输温度:

-80
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Lyophilized from sterile 20mM Tris, pH 7.4, with 500 mM sodium chloride and 10% glycol
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365
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美国
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≥90% estimated by SDS-PAGE
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