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PDE1B1 (human, recombinant)
品牌： Cayman
产品货号： 32040
规格： 50 µg

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折后价：

数量： - +
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  • 产品名称:
    PDE1B1 (human, recombinant)
  • 别名:
    Calcium/Calmodulin-dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B|Cam-PDE 1B|Phosphodiesterase 1B1
  • 产品描述:
    Phosphodiesterase 1B (PDE1B) is a calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase that hydrolyzes both cAMP and cGMP.{56071} Alternative splicing of PDE1B pre-mRNA results in the formation of various PDE1B isoforms, including PDE1B1.{56072} PDE1B1 is comprised of an N-terminal calmodulin binding domain, a catalytic domain, and a C-terminal domain.{56071} PDE1B1 is expressed in the brain, with the highest levels observed in the caudate nucleus and putamen.{56072} PDE1B knockout mice have decreased striatal serotonin levels and exhibit increased spontaneous locomotor activity in a novel environment, as well as increased methamphetamine-induced locomotor activity compared with wild-type mice.{56073} Striatal expression of PDE1B is decreased in the R6/2 transgenic mouse model of Huntington's disease.{56074} Cayman's PDE1B1 (human, recombinant) protein consists of 773 amino acids and has a calculated molecular weight of 89.2 kDa.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    Lyophilized from sterile 50 mM Tris, pH 8.0, with 100 mM sodium chloride
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  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥94% estimated by SDS-PAGE
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