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产品名称:
IDH1 (human recombinant)
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别名:
Isocitrate Dehydrogenase (NADP) Cytoplasmic
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产品描述:
Isocitrate dehydrogenases (IDHs) are NAD+ and NADP+-dependent enzymes that catalyze the third step of the tricarboxylic acid cycle. IDHs catalyze oxidative decarboxylation of isocitrate producing α-ketoglutarate and carbon dioxide. IDH1 (cytosolic) and IDH2 (mitochondrial) are NADP+-dependent enzymes that catalyze reversible reactions. The IDH3 isoform, a NAD+-dependent multisubunit enzyme, is irreversible and allosterically regulated by a variety of positive (calcium, ADP, and citrate) and negative (ATP, NADH, and NADPH) effectors.{22137} IDH1 and IDH2 are mutated in >70% of lower grade gliomas.{22138}
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阳性对照:
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保存温度:
-80
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运输温度:
-80
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产品形式:
50 mM Tris-HCl, pH 7.5, containing 200 mM sodium chloride, 5 mM β-mercaptoethanol, 50 mM calcium chloride, and 20% glycerol
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存储溶液:
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有效期:
365
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产地:
美国
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纯度:
≥90% estimated by SDS-PAGE
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