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GDP-L-Fucose Synthase (human, recombinant)
品牌： Cayman
产品货号： 26695
规格： 100 µg

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数量： - +
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  • 产品名称:
    GDP-L-Fucose Synthase (human, recombinant)
  • 别名:
    GDP-4-keto-6-deoxy-D-Mannose-3,5-Epimerase-4-Reductase|Protein FX|Red Cell NADP(H)-Binding Protein|Short-Chain Dehydrogenase/Reductase Family 4E Member 1|Tissue Specific Transplantation Antigen P35B|TSTA3
  • 产品描述:
    GDP-L-Fucose synthase, encoded by the gene TSTA3, is an NADP(H)-binding protein that catalyzes the final step in the synthesis of GDP-L-fucose from GDP-D-mannose.{42819,42820} It converts GDP-4-keto-6-deoxy-D-mannose to GDP-L-fucose via a two-step reaction consisting of epimerization followed by NADPH-dependent reduction. GDP-L-Fucose synthase exists as a homodimer and is comprised of an N-terminal NADPH-binding domain and a C-terminal substrate-binding domain. TSTA3-/- mice exhibit increases in colonic inflammation, dysplasia, and epithelial permeability, which are reversed following addition of fucose to the diet.{42821} These mice also exhibit alterations in gut microflora and increased bacterial burden in colon transluminal tissue and feces when fed a normal diet versus a fucose-supplemented diet, and the colonic effects of TSTA3 deletion can be reversed following administration of antibiotics. GDP-L-Fucose synthase has been identified as an autoantigen that can be recognized by CD4+ T cells derived from patients with multiple sclerosis.{42822} Expression of GDP-L-fucose synthase in primary tumor tissue samples from patients with esophageal squamous cell carcinoma (ESCC) positively correlates with increased clinical stage, lymph node metastasis, and poor prognosis.{42823}
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol
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  • 有效期:
    365
  • 产地:
    美国
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    ≥90% estimated by SDS-PAGE
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