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Ubiquitin (human, recombinant)
品牌： Cayman
产品货号： 20487
规格： 1 mg

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数量： - +
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  • 产品名称:
    Ubiquitin (human, recombinant)
  • 别名:
  • 产品描述:
    Ubiquitin is a regulatory protein encoded by three gene classes in humans, which code for fusion proteins between ubiquitin and zinc-finger proteins, ribosomal proteins, or ubiquitin repeats that are cleaved by esterases to release monomeric ubiquitin.{17707,17708} It is ubiquitously expressed and highly conserved among eukaryotic species. Ubiquitin is conjugated to misfolded, abnormal, short-lived, or foreign proteins by ubiquitin-conjugating enzymes (E2) and substrate-specific ubiquitin ligases (E3) to target them for degradation by the 26S proteasome or lysosome.{17707,26608} It is also conjugated to proteins to modify cell signaling through regulation of protein-protein interactions, activity, or subcellular localization.{26608} Dysregulation of ubiquitination has been implicated in the pathogenesis of neurodegenerative diseases, including Parkinson’s and Alzheimer’s diseases.{58819} Cayman’s Ubiquitin (human, recombinant) protein can be used as a substrate for enzyme activity assays.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM Tris, pH 7.5, with 150 mM sodium chloride and 5% glycerol
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • 纯度:
    ≥95% estimated by SDS-PAGE
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