产品描述:
Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively.{33921,33920} It is selective for JNKs over a panel of 25 related kinases.{33921} Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis.{33922,33924} It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.{33920,33923}