产品描述:
R428 is a small molecule inhibitor of Axl kinase, both in an in vitro biochemical assay and in a cell-based assay using phosphorylation of Ser473 on Akt as the readout (EC50s = 14 nM for both).{33459} It is orally bioavailable, blocks angiogenesis in corneal micropocket and tumor models, and reduces metastatic burden while extending survival in mouse models of breast cancer metastasis.{33459} R428 synergizes with cisplatin (Item No. 13119) to enhance suppression of liver micrometastasis.{33459} R428 is used to study the role of Axl kinase signaling in cancer, cellular senescence, and Zika virus infection.{33458,33460,33461}