产品描述:
TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.{28066} It is orally active, stable, and crosses the blood-brain barrier.{28066} The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.{28066} TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.{28066}