产品描述:
GNF-2 is an allosteric inhibitor of Bcr-Abl (IC50 = 267 nM).{28970} It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 µM. It inhibits proliferation of Ba/F3 cells (IC50 = 138 nM). GNF-2 (10 µM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion.{45828} It inhibits LPS-induced production of nitric oxide (NO) and TNF-α in BV-2 microglia when used at concentrations of 10 and 20 µM.{59702} GNF-2 (1 and 10 mg/kg) reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA). It also decreases mechanical and thermal hyperalgesia in a mouse model of diabetic neuropathy induced by streptozotocin (STZ; Item No. 13104).