产品描述:
Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1.{27537} SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 µM).{27539} It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4.{27539} SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells.{27539,27538} By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.{27543,27541,27540}