产品描述:
Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis.{37029,37026} In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM).{37028} It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM).{37025} Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil (Item No. 14416), cisplatin (Item No. 13119), bleomycin (Item No. 13877), mitomycin C (Item No. 11435), and 6-mercaptopurine.{37027} It is an oxidized form of ansatrienin B (Item No. 21996).{37026}