产品描述:
Hemin chloride is an oxidized form of heme that inhibits eukaryotic translation initiation factor 2α kinase 1 (eIF2αK1), a repressor of eIF-2α.{32368} This alters the initiation of mRNA translation, evoking a wide array of cellular effects. Hemin chloride is used experimentally to induce the expression of heme oxygenase-1 in cells and in animals.{32369,32367,32365} Heme extracted from blood is usually oxidized to hemin chloride.{32366,32364} In porphyria, disorders resulting from an increase in porphyrins, hemin chloride serves to activate feedback inhibition of δ-aminolevulinic acid synthase, reducing heme biosynthesis.{32364}