产品描述:
PIK-93 is an inhibitor of phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ; IC50 = 19 nM).{14312} It is selective for PI4KIIIβ over PI4KIIIα and PI4KIIα (IC50s = 1,100 and >100,000 nM, respectively). However, it also inhibits the PI3K catalytic subunits (IC50s = 39, 590, 120, and 16 nM for p110α, p110β, p110δ, and p110γ, respectively). PIK-93 reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells.{36235} It also inhibits the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus.{36236}