产品描述:
AZD 7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK; IC50 = 0.63 nM in an enzyme assay).{48616} It is selective for DNA-PK over TTK (IC50 = 5.012 μM), as well as JAK1, JAK2, JAK3, Aurora A, and Aurora B (IC50s = >10 μM for all). AZD 7648 reduces tumor growth in a FaDu ATM KO pharynx cancer mouse xenograft model when administered at doses of 37.5 or 75 mg/kg twice per day and induces tumor regression at these doses when administered in combination with the PARP inhibitor olaparib (Item No. 10621).