产品描述:
DB07268 is a potent inhibitor of JNK1 (IC50 = 9 nM) that binds to the ATP site of JNK1.{40395} It is selective for JNK1 over P38, ERK2, AKT1, CHK1, and PAK4 among others. DB07268 did not reduce phosphorylation of insulin resistance substrate 1 (IRS-1) in HEK293 cells.{40396}