产品描述:
NMS-1286937 is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM).{20485} It is selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both). It inhibits proliferation of A2780 cells with an IC50 value of 42 nM. NMS-1286937 halts the cell cycle at the G2/M phase in A2780 cells when used at a concentrations ranging from 20 to 200 nmol/L and induces apoptosis.{52131} It reduces tumor growth in an HCT116 mouse xenograft model when administered at a dose of 60 mg/kg once per day.{20485} NMS-1286937 (45 mg/kg) also induces tumor regression in an HT-29 mouse xenograft model when administered in combination with CPT11 (irinotecan; Item No. 14180).{52131}