产品描述:
Terreic acid (TA) is a cell-permeable quinone epoxide that selectively inhibits Bruton’s tyrosine kinase (BTK) catalytic activity (IC50s = 10 and 3 µM for basal and activation levels, respectively).{31003,38003,38004} TA binds to the BTK pleckstrin homology domain (BTK-PH) and blocks the interaction between BTK-PH and PKC (IC50 = 100 µM in human mast cell lysates) without affecting the activity of PKC.{38003,38004} TA has minimal effect on Lyn, Syk, PKA, casein kinase I, ERK1, ERK2, and p38 kinase activities.{38004,38005}