产品描述:
Triciribine is an Akt activation inhibitor and a prodrug form of triciribine phosphate (Item No. 37985).{15002,66386} It reduces levels of phosphorylated Akt1, -2, and -3 in Akt-overexpressing NIH3T3 cells when used at a concentration of 1 µM.{15002} Triciribine is selective for Akt1, -2, and -3 over a panel of seven other Akt-activating kinases at 1 µM. It reduces the proliferation of L1210 mouse leukemia cells when used at concentrations of 0.05, 0.2, and 1 µM.{66386} Triciribine (1 µM) induces cell cycle arrest at the G1 phase in L1210 cells.{15002} It reduces viral plaque formation in CEM-SS cells and human foreskin fibroblasts (HFFs) infected with HIV-1 and human cytomegalovirus (CMV), respectively (IC50s = 0.02 and 2 µM, respectively).{66387} It inhibits tumor proliferation in an OVCAR-3 ovarian cancer mouse xenograft model when administered at a dose of 1 mg/kg per day.{15002}