产品描述:
Everolimus-d4 is intended for use as an internal standard for the quantification of everolimus (Item No. 11597) by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin (Item No. 13346) that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM.{24850,24847} It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin.{24847} Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer.{24849,24846} It also acts as an immunosuppressive agent in the context of organ transplantation.