产品描述:
IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) that inhibits CK1δ and CK1ɛ (IC50 = ~1 µM for both), as well as CK1α (IC50 = 16 µM).{28923} It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn.{28923} IC 261, at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts.{28921} IC261 is used to elucidate the role of CK1 in cells and in whole organisms.{28925,28924,28922}