产品描述:
AZD 2014 is a potent, selective, ATP-competitive mTORC1/2 dual inhibitor that inhibits phosphorylation of both mTORC1 and 2 substrate proteins in whole cells.{33186} It exhibits an IC50 value of 2.81 nM against the isolated recombinant enzyme and >1,000-fold selectivity against all PI3K isoforms.{33186} AZD 2014 has broad antiproliferative effects across multiple cell lines and reduces tumor growth in in vivo models of ER+ breast cancer.{33186}. It has efficacy against acute myeloid leukemia when combined with the pan Pim kinase inhibitor AZD 1208 (Item No. 20235) and enhances the radiosensitivity of different cancer cell types.{32019,33187,33188}