产品描述:
AMG 319 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform δ (PI3Kδ; IC50 = 18 nM) that less effectively targets the α, β, and γ isoforms (IC50s = 33, 2.7, and 0.85 µM, respectively).{32332} It blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation (IC50 = 1.5 nM) in B cells.{32332} AMG 319 is orally bioavailable and reduces inflammation in two animal models.{32332}