产品描述:
SAR260301 is an inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform β (IC50 = 52 nM).{34311} It is selective for p110β over other PI3K isoforms.{34311} SAR260301 demonstrates significant in vivo activity in a UACC-62 xenograft model in mice.{34311} It has synergistic antitumor activity when combined with the BRAF inhibitor vemurafenib (PLX4032; Item No. 10618) or the MEK inhibitor selumetinib (AZD 6244; Item No. 11599) in PTEN-deficient/BRAF-mutated human melanoma tumor models.{34310}