产品描述:
Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol (Item No. 20347) that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties.{53372,53373,53374,53375,53376,53377} It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 µg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 µg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC50 = 55 µM).{53372,53374} Purpurogallin (2, 5, and 10 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes.{53373} It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC50s = 27.5, 8, 16, and 50 µM, respectively), as well as catechol O-methyltransferase (COMT; Ki = 0.074 µM), in cell-free assays.{53372,53374,53375,53376,53377}