产品描述:
Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM).{28657,28655} It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions.{28655,28656,28658} VE-821 also sensitizes cancer cells to chemotherapy.{28656,28654,28573}