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Suramin (sodium salt)
品牌: Cayman
产品货号: 11126-100 mg
规格: 100 mg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    Suramin (sodium salt)
  • 别名:
    BAY 205|Germanin|NF 060
  • 产品描述:
    Suramin is a polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities.{62519} It is negatively charged at physiological pH and therefore binds to various intracellular targets including, but not limited to, ryanodine receptor 1 (IC50 = 4.9 µM), G protein-coupled receptors, P2 purinergic receptors, PDGF, PKC, transferrin, DNA and RNA polymerases, sirtuins, and various cytokines.{62519,23034,23035} It reduces Zika virus infectivity in Vero cells (IC50 = ~2.5-5 µg/ml).{62520} In vivo, suramin induces cell cycle arrest at the G2/M phase and apoptosis in L. donovani promastigotes in vitro and reduces hepatic parasitic burden in a mouse model of L. donovani-induced visceral leishmaniasis.{62521} It also neutralizes the myotoxic effect of basic phospholipase A2 (PLA2) homolog MjTX-I, a Lys49-PLA2 protein from snake venom, in mouse phrenic-diaphragm preparations.{69266} Suramin (60 mg/kg) reduces tumor volume in patient-derived xenograft (PDX) mouse models of malignant mesothelioma.{62522} Formulations containing suramin have been used in the treatment of African sleeping sickness.
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  • 阳性对照:
  • 保存温度:
    22
  • 运输温度:
    22
  • 细胞定位:
  • 预期分子量:
    1429.1
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥98%
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  • CAS号:
    129-46-4
  • 分子式:
    C51H34N6O23S6 • 6Na
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