产品描述:
PF-04217903 is an inhibitor of c-Met (Ki = 4.8 nM).{29778} It is greater than 1,000-fold selective for c-Met over a panel of 150 kinases. PF-04217903 inhibits the proliferation of and induces apoptosis in GTL-16 gastric carcinoma cells (IC50s = 12 and 31 nM, respectively) as well as inhibits migration of NCI H441 lung cancer cells induced by hepatocyte growth factor (HGF; IC50 = 11 nM). It reduces tumor growth in a GTL-16 mouse xenograft model when administered at doses ranging from 1 to 30 mg/kg.