产品描述:
Receptors for VEGF have central roles in vasculogenesis and angiogenesis and thus serve as targets for cancer therapy.{18368,20203} Cediranib is a potent inhibitor of VEGF receptor tyrosine kinases, including VEGFR1, 2, and 3 (IC50s = 5, 1, and 3 nM, respectively).{24157} It also potently inhibits a variety of other receptor and non-receptor tyrosine kinases, including several in the platelet-derived growth factor, fibroblast growth factor, and endothelial growth factor receptor families.{24157,24156} Cediranib blocks tubule formation by human umbilical vein endothelial cells in vitro and prevents angiogenesis as well as xenograft tumor growth in vivo.{24157} Because of these effects, cediranib has potential use in a range of cancers.{19939,24159,24155}