产品描述:
IC-87114 is a cell-permeable selective inhibitor of the PI3K catalytic subunit p110δ (IC50 = 0.5 μM).{24748} It less effectively inhibits p110γ and p110β (IC50 = 29 and 75 μM, respectively) and has no significant effect on p110α and several other kinases.{24748,24749} This product is used to elucidate the role of p110δ in cells, including neutrophils, natural killer cells, and other types of leukocytes.{24748,24749,24750,21846,24751} It has also been used in mice.{24752}