产品描述:
Enzastaurin is a potent inhibitor of PKCβ (IC50 = 6 nM), with modest selectivity over PKCα, PKCγ, and PKCε (IC50 = 39, 83, and 110 nM, respectively).{24308} At 3 µM, enzastaurin also inhibits signaling through the Akt pathway.{24306} It suppresses angiogenesis, induces apoptosis, and reduces proliferation of cultured tumor cells.{24308,24306} Because of these effects, enzastaurin has potential antineoplastic activity.{24307}