产品描述:
Halicin is a JNK1 inhibitor (IC50 = 0.7 µM).{58266,58267} It is selective for JNK1 over p38α, Furin, and lethal factor (IC50s = >100, >100, and >50 µM, respectively), as well as Akt at 100 µM.{58266} Halicin inhibits TNF-α-induced phosphorylation of c-Jun in a cell-based assay (EC50 = 6.23 µM). In vivo, halicin (25 mg/kg) reduces blood glucose levels and restores insulin sensitivity in insulin insensitive mice. Halicin is active against carbapenem-resistant Enterobacteriaceae (MICs = 1-10 µg/ml), as well as multidrug-resistant A. baumannii and P. aeruginosa (MICs = 1-10 and 1-100 µg/ml, respectively).{58267} It reduces the number of wound tissue colony forming units (CFUs) in a mouse model of A. baumannii wound infection. Halicin (15 mg/kg) also reduces fecal bacterial load in a mouse model of C. difficile infection.