产品描述:
Schizandrin B is a dibenzocyclooctadiene that has been found in F. schisandrae and S. chinensis with diverse biological activities.{42179,42180,42181} Schizandrin B (50 μM) completely inhibits anti-CD3- and anti-CD28-induced release of the cytokines IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells.{42182} In A549 adenocarcinoma cells, schizandrin B (1-30 μM) dose-dependently reduces cell survival and UV-induced phosphorylation of p53 and checkpoint kinase 1 (Chk1).{42179} Schizandrin B reduces kinase activity of the serine/threonine-protein kinase ATR with an IC50 value of 7.25 μM for the recombinant enzyme. In vivo, schizandrin B (25-100 mg/kg, p.o.) dose-dependently inhibits lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production induced by doxorubicin (Item No. 15007) in mouse heart.{42180} It also reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and matrix metalloproteinase-2 (MMP-2) and MMP-9. Schizandrin B (1 or 2 mmol/kg per day, p.o.) pretreatment reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases glutathione (GSH) levels and Se-glutathione peroxidase (GSH-Px) activity in brain in mice.{42181}