产品描述:
Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy.{21810} Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively).{30416} It less potently inhibits GSK3β (IC50 = 1 µM) and does not block Cdc25 activity.{30416} This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.{30414,30415,30417}