产品描述:
Alkannin is a naphthoquinone and enantiomer of shikonin (Item No. 14751) that has been found in A. tinctoria and has diverse biological activities.{23515,45363,45364,45365,45366} It inhibits tumor-specific pyruvate kinase M2 (PKM2; IC50 = 0.3 μM) with 20- and 10-fold selectivity over PKM1 and pyruvate kinase L (PKL), respectively.{23515} Alkannin inhibits proliferation of HCT116 and SW480 colorectal cancer cells with IC50 values of 2.38 and 4.53 μM, respectively.{45363} It halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells when used at a concentration of 3 μM. Alkannin (1 μM) increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells.{45364} It is active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively).{45365} Alkannin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (EC50 = 22 ppm).{45366}