产品描述:
SB 239063 is a selective p38 MAPK inhibitor (IC50 = 44 nM for recombinant purified p38α).{30980} It displays greater than 220-fold selectivity for p38 MAPK over ERK, JNK1, and other kinases.{30980} SB 239063 has been shown to reduce inflammatory cytokine production in lipopolysaccharide-stimulated human peripheral blood monocytes (IC50s = 0.12 and 0.35 µM, respectively for IL-1 and TNF-α) and is neuroprotective following oral administration in a rat model of cerebral focal ischemia.{30980,30979}