产品描述:
Micheliolide is a sesquiterpene lactone and derivative of parthenolide (Item No. 70080) that has been found in M. champaca and has diverse biological activities.{43087,57386,57387,57388} It is an irreversible activator of the pyruvate kinase M2 isoform (PKM2; EC50 = 6 nM) that decreases viability of HL-60 cells when used at concentrations ranging from 5 to 20 µM.{43087} Micheliolide (5-10 µM) reduces M. tuberculosis-induced secretion of IL-1β and TNF-α, expression of Cox2, and production of nitric oxide (NO) in RAW 264.7 cells.{57386} It also inhibits M. tuberculosis-induced NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in RAW 264.7 cells. Micheliolide (30 mg/kg) decreases the severity of collagen-induced arthritis (CIA) in a mouse model of rheumatoid arthritis.{57387} It also increases hepatic protein levels of PPARγ and reduces hepatic inflammation and steatosis in db/db mice.{57388}