产品描述:
LXS-196 is a PKC inhibitor (IC50s = 1.9 and 0.4 nM for PKCα and PKCθ, respectively).{52782} It is selective for PKCα and PKCθ over GSK3β (IC50 = 3,100 nM). It inhibits proliferation of TMD8 B cell lymphoma and 92.1 uveal melanoma cells (IC50s = 900 and 184 nM, respectively) but not SK-MEL-28 skin melanoma cells (IC50 = >10,000 nM).