产品描述:
9-Methoxyellipticine is an alkaloid and a derivative of the DNA intercalating agent ellipticine (hydrochloride) (Item No. 18742) that has been found in O. maculata and has anticancer activity.{60369,60370} It intercalates into DNA and is an inhibitor of wild-type c-Kit and c-Kit containing the D816V activating mutation (c-KitD816V; IC50s = 0.8 and 0.6 µM, respectively).{60370,60371} 9-Methoxyellipticine inhibits proliferation of Ba/F3 cells in the presence of the c-Kit ligand SCF and Ba/F3 cells expressing c-KitD816V (IC50s = 0.5 and 0.3 µM, respectively).{60370} It also increases survival in a variety of rodent tumor models.{60369}