产品描述:
INK1117 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC50 = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR) and in cells when used at 1 µM.{31648,31649} It blocks signaling to Akt and inhibits growth of cancer cells harboring wild-type or mutated p110α.{31648} INK1117 does not interfere with B cell proliferation or NK cell maturation and survival.{31648,31649}