产品描述:
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.{31456}. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM.{31456} This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.{31456}