产品描述:
Uprosertib is a selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively).{32165} Uprosertib preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation via PI3K/PTEN mutation or loss.{30969} It can cause cell cycle arrest and consequent tumor growth inhibition in mice bearing either BT474 breast tumor or SKOV3 ovarian tumor xenografts.{30969}