产品描述:
AZ 32 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = 50s = 4.6 and >4.6 µM, respectively). AZ 32 enhances radiation-induced cytotoxicity in a panel of five human glioma cells expressing wild-type or mutant p53. It increases survival in a U87-281G glioma orthotopic mouse xenograft model, as well as a NCI H2228 non-small cell lung cancer (NSCLC) mouse xenograft model of metastatic brain tumors, when administered at doses of 200 and 50 mg/kg, respectively, in combination with ionizing radiation.