产品描述:
ZM 449829 is a degradation product of ZM 39923 (Item No. 16729) and an inhibitor of JAK3 (IC50 = 0.158 µM).{27341,59766} It is selective for JAK3 over EGFR and JAK1 (IC50s = 10 and 19.95 µM, respectively) but does inhibit human tissue transglutaminase 2 (TGM2) and transglutaminase factor XIIIa (FXIIIa; IC50s = 0.005 and 0.006 µM, respectively).{27341,22726} ZM 449829 decreases the formation of cancer stem cells (CSC) within MCF-7-derived mammospheres.{59765} It decreases migration of, and colony formation by, MCF-7 cells when used at a concentration of 10 µM. ZM 449829 (10 µM) also inhibits formation of replication vacuoles in C. burnetii-infected HeLa and THP-1 cells.{59764}