产品描述:
DSP-4 is an alkylating agent and a noradrenergic neurotoxin that inhibits the uptake of norepinephrine in rat cortical homogenates.{39935} It reduces dopamine-β-hydroxylase activity in rat brain and selectively depletes norepinephrine in rat cortex and locus coeruleus over the ventral forebrain, hypothalamus, and periphery.{39936,39935} DSP-4 (50 mg/kg) impairs tactile learning in the novel object recognition task in rats.{39937} It also decreases exploration in a novel open area and neophilia in a complex exploration test in rats.{39938}