产品描述:
Edicotinib is an inhibitor of colony stimulating factor 1 receptor (CSF1R; IC50 = 3.2 nM).{54821} It is selective for CSF1R over KIT and FMS-related tyrosine kinase 3 (FLT3; IC50s = 20 and 190 nM, respectively). Edicotinib (0.1-1,000 nM) reduces CSF1-induced phosphorylation of CSF1R and ERK1/2 in N13 microglia. It reduces spinal motor neuron degeneration and increases the latency to fall in the rotarod test in the P301S mouse model of tauopathy. Edicotinib (15 mg/kg) reduces increases in the colonic weight-to-length ratio, as well as decreases colonic infiltration of macrophages, neutrophils, and CD3+ T cells, in an adoptive T cell transfer-induced mouse model of colitis.{54822} It also reduces the viability of L-1236 Hodgkin lymphoma cells with an IC50 value of 264 nM.{54823}