产品描述:
TAS 301 (10 μM) impedes Ca2+ mobilization and Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) activation that inhibits vascular smooth muscle cell (VSMC) proliferation in vitro.{34683,34682} At a concentration of 10 μM, TAS 301 also inhibits platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of focal adhesion kinase and paxillin and promotes cytoskeletal rearrangment.{34683} TAS 301 (3-100 mg/kg) inhibits migration and proliferation of VSMCs and prevents arterial intimal thickening in vivo in a model of balloon-injured arteries in rats.{34680} In a micro pig model, TAS 301 administration (30-100 mg/kg) prevents coronary artery stenosis after balloon overstretch injury.{34681}