产品描述:
BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively.{32445} LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin.{32443,32444} This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin.