产品描述:
CGP 77675 is an inhibitor of Src family kinases (SFKs) that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively).{33451} It also inhibits the SFKs Lck and c-Yes with low nanomolar IC50 values.{33451,33450,33453} CGP 77675 is used to elucidate the role of SFKs in such processes as bone resorption, tight junction formation in epithelial cells, and allograft survival.{33450,33451,33454} It can also be used in combination with the GSK3 inhibitor CHIR99021 (Item No. 13122) to maintain mouse embryonic stem cells.{33452}