产品描述:
Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins,{18298,18299} as well as in some cancers.{18300} Sphinganine can block protein kinase C activation in some cases but not others.{18301,15200} Sphinganine-1-phosphate can emulate sphingosine-1-phosphate in cell signaling or have opposite intracellular effects.{18297,18302,18303}