产品描述:
CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens.{18020} They mediate the metabolism of xenobiotics as well as certain endobiotics, including steroid hormones.{18021} CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens.{18020} They mediate the metabolism of xenobiotics as well as certain endobiotics, including steroid hormones.{18021} 6β-hydroxy Testosterone is a major metabolite produced from testosterone by the actions of CYP3A4 and CYP3A5, accounting for 75-80% of all metabolites formed from testosterone.{18021,313} The biological effects of 6β-hydroxy testosterone have been poorly studied.